Zopolrestat,110703-94-1

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Zopolrestat

CAS No. : 110703-94-1

MCE 国际站：Zopolrestat

产品活性：Zopolrestat (CP73850) 是一种有效的、具有口服活性的醛糖还原酶 (aldose reductase) 抑制剂，其IC₅₀ 为3.1 nM。Zopolrestat 用于糖尿病并发症的研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Aldose Reductase

In Vitro: Zopolrestat is a potent inhibitor of the reduction of both glyceraldehyde and glucose by the human and rat enzymes.

In Vivo: Zopolrestat (2.5 mg/kg-50 mg/kg; p.o.; once-a-day for 5 days) and left untreated for 7 days) prevents accumulation of sorbitol in the kidney cortex of diabetic rats and normalize elevated renal blood flow in galactosemic rats.

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