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- 保存条件:
4°C, sealed storage, away from moisture and light
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
94987-10-7
- 规格:
1 mg/5 mg/10 mg
| 规格: | 1 mg | 产品价格: | ¥1200.0 |
|---|---|---|---|
| 规格: | 5 mg | 产品价格: | ¥3200.0 |
| 规格: | 10 mg | 产品价格: | ¥5200.0 |
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Gypenoside LI
CAS No. : 94987-10-7
MCE 国际站:Gypenoside LI
产品活性:Gypenoside LI 是一种绞股蓝赶单体,具有抗肿瘤活性。Gypenoside LI 诱导癌细胞凋亡、细胞周期阻滞和迁移。
研究领域:Apoptosis | Epigenetics
In Vitro: Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells.
Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells.
Gypenoside LI could obviously suppress the expression of CDK1 protein rather thanCDK2 and CDK4 proteins.
Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells.
Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway.
Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells.
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