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文献和实验Preventing Immune Rejection Through Gene Silencing
that DC maturation is associated with activation of the NF-κB pathway. RelB, one of the five families of Rel proteins involved in the NF-κB pathway, plays a critical role in coordinating the terminal stages of DC maturation and has the ability to induce
【进展|热点】Nature Immunology:发现三个调控NF-kB非经典信号通路的microRNA
://www.nature.com/ni/journal/v11/n9/abs/ni.1918.html 内容简介: NF-κB是一组重要的转录因子,参与了诸多免疫反应过程,其中最为人熟知的就是在天然免疫中,NF-κB是最终启动炎症因子表达的因素之一。 NF-κB家族包括5个成员,即RelA(p65)、RelB、c-Rel、p105-p50(NF-κB1)和p100-p52(NF-κB2),两两形成同源或者异源二聚体的形式发挥作用。通常情况下,NF-κB与其抑制蛋白IκB(包括IκBα、IκBβ
Activation of Nuclear Factor-B (NF-B) in Mononuclear Cells (MNC)
is a heterodimer, which usually consists of two proteins, a p65 (relA) subunit and a p50 subunit. Other subunits (rel, relB, v-rel, and p52) can also bind to the activated NF-κB and thus can activate different sets of genes.








