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文献和实验Pharmacology, Biodistribution, and Efficacy of GPCR-Based Pepducins in Disease Models
against a wide variety of GPCRs including the protease-activated receptors (PAR1, 2, 4), the chemokine receptors (CXCR1, 2, 4), the sphingosine-1-phosphate receptor (S1P3), the adrenergic receptor (ADRA1B), and have the potential to help reveal the functions
Examples of Involvement in Disease CCR5 provides a signal for microbial induced production of IL-12 by CD8+ dendritic cells Regulation of tyrosine kinase activation and granule release through -arrestin by CXCR1
让肿瘤变「热」!宋尔卫院士团队Nat Immunol发文报道肿瘤免疫治疗新策略
(2019).9. L. Jin et al., CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors. Nat Commun 10, 4016 (2019).10. L. Zhao, Y. J. Cao, Engineered T Cell Therapy for Cancer in the Clinic. Front Immunol 10, 2250 (2019









