IGF BP3; IGF-BP3; Acid stable subunit of the 140 K IGF complex; Binding protein 29; Binding protein 53; BP 53; BP53; Growth hormone dependent binding protein; IBP 3; IBP3; IGF binding protein 3; IGFBP 3;IGFBP-3; Insulin Like Growth Factor Binding Protein 3; IBP3_HUMAN.
研究领域
肿瘤 细胞生物 免疫学 生长因子和激素 糖尿病
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Rat, (predicted: Mouse, Pig, Cow, Horse, Sheep, )
产品应用
WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
32kDa
细胞定位
分泌型蛋白
性 状
Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human IGFBP3:131-231/292
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
GFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Subcellular Location: Secreted.
Tissue Specificity: Expressed by most tissues. Present in plasma.
Post-translational modifications: Phosphorylation sites are present in the extracelllular medium.