- ￥1200
- Biorigin
- BN41644R
- 2025年08月10日
- WB,
- Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 适应物种：
Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,
- 应用范围：
WB,
- 抗体英文名：
PI3 Kinase p110 beta
- 规格：
50ul
| 英文名称 | PI3 Kinase p110 beta |
| 中文名称 | 磷脂酰肌醇激酶（PI3Kβ）抗体 |
| 别 名 | PI3-kinase p110 subunit beta; p110 BETA; p110Beta; PI3K beta; Phosphatidylinositol 3 kinase catalytic beta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform; Phosphatidylinositol-4; Phosphoinositide 3 kinase catalytic beta polypeptide; PI3 kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K beta; PI3K-beta; PI3Kbeta; PI3KCB; PIK3C1; Pik3cb; PK3CB_HUMAN; PtdIns 3 kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; 5-bisphosphate 3-kinase catalytic subunit beta isoform. |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 细胞周期蛋白 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, (predicted: Dog, Cow, Horse, Rabbit, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 123kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PI3 Kinase p110 beta:971-1070/1070 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]. Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Subunit: Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4. Interacts with BECN1, ATG14 and RAB5A. Subcellular Location: Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export. Tissue Specificity: Expressed ubiquitously. Post-translational modifications: Phosphorylation at Ser-1070 down-regulates lipid kinase activity. Similarity: Belongs to the PI3/PI4-kinase family. Contains 1 C2 PI3K-type domain. Contains 1 PI3K-ABD domain. Contains 1 PI3K-RBD domain. Contains 1 PI3K/PI4K domain. Contains 1 PIK helical domain. SWISS: P42338 Gene ID: 5291 Database links: Entrez Gene: 5291 Human Entrez Gene: 74769 Mouse Omim: 602925 Human SwissProt: P42338 Human SwissProt: Q24JU2 Human SwissProt: Q3U4Q1 Mouse SwissProt: Q8BTI9 Mouse Unigene: 239818 Human Unigene: 213128 Mouse Unigene: 44268 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验相关实验
的活化： PI3K 有很多种类别，不过只有第 I 类能够响应生长刺激而磷酸化脂质。I 类的 PI3K 是异源二聚体，其亚基为 p85（调控）与 p110（催化）。磷脂酰肌醇的形成：活化的 PI3K 催化磷酸基团到磷酸肌醇的肌醇环上的 3『-OH 位置的加成反应，反应有三种脂质产物， PI (3) P, PI (3,4) P2 和 PI (3,4,5) P3，这些磷酸化的脂质被锚定在细胞膜上，并且可以直接结合细胞内包含 PH 或 FYVE 结构域的蛋白。Akt 的活化：Akt 以非活化构象驻留在细胞
了条件。这里，被CD28分子胞内段磷酸化ITAM招募的不是ZAP-70，而是上面提到的另一类带有SH2结构域的PI3K。 磷脂肌醇的代谢和PI3K的作用 PI：磷脂酰肌醇；P：磷酸；K：激酶。 PI3K在磷酸肌醇(phosphoinositide)的磷酸化和代谢中十分活跃。磷酸肌醇代谢主要涉及PI，该分子中有一个肌醇环，环中的第3、第4、第5位置可以发生磷酸化。其中，使第3第4位羟基发生磷酸化的酶，分别称为PI3K和PI4K。从上到下是在这些激酶的作用下，第4、第5位羟基
分布却很相似。围绕许多神经细胞轴突并使之绝缘的髓鞘质含鞘磷脂特别丰富。因含磷，鞘磷脂也可归入磷脂。 脑苷脂 （ cerebroside）不含磷，常呈中性。其极性头含糖。最简单的脑苷脂为存在于脑细胞膜中的半乳糖脑苷脂，其极性头基为β -D-半乳糖。葡糖脑苷脂存在于其他组织的膜中，其极性头含β -D-葡萄糖。某些半乳糖脑苷脂的 3位碳被硫酸化，称为脑硫脂。更复杂的脑苷脂的极性头含有 4个以上糖基组成的不分支寡糖链。 神经节苷脂 （ ganglioside）是最复杂的鞘脂
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磷脂酰肌醇激酶（PI3Kβ）抗体
￥1200
