蛋白酶体26S亚基ATP酶3相互作用蛋白抗体

英文名称PSMC3IP中文名称蛋白酶体26S亚基ATP酶3相互作用蛋白抗体别    名26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; Human immunodeficiency virus tat transactivator binding protein 1; MGC8487; Proteasome (prosome macropain) 26S subunit ATPase 3; Proteasome 26S ATPase subunit 3; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; PRS6A_HUMAN; PSMC 3; PSMC3; Tat binding protein 1; TAT-binding protein 1; TBP-1; TBP1.  研究领域细胞生物  转录调节因子  泛素  抗体来源Rabbit克隆类型Polyclonal交叉反应Mouse,  (predicted: Human, Rat, Dog, Horse, Rabbit, )产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量24kDa细胞定位细胞核 性    状Liquid浓    度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human PSMC3IP:1-100/217 亚    型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed产品介绍This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Function:
Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in testis and colon.

Post-translational modifications:
PTM: Phosphorylated by PKA, PKC and MAPK.

DISEASE:
Ovarian dysgenesis 3 (ODG3) [MIM:614324]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the HOP2 family.

SWISS:
Q9P2W1

Gene ID:
29893

Database links:
ntrez Gene: 29893 Human

Entrez Gene: 19183 Mouse

Entrez Gene: 140938 Rat

Omim: 608665 Human

SwissProt: Q9P2W1 Human

SwissProt: O35047 Mouse

SwissProt: Q91ZY6 Rat

Unigene: 383019 Human

Unigene: 18344 Mouse

Unigene: 144650 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.