一种合成的α2-adrenaline受体拮抗剂, Ki值为1.6 nM。
Atipamezole is an adrenergic α2 antagonist. Atipamezole alters the behavioural effects of pramipexole and increases pramipexole concentration in blood plasma. Atipamezole reverses ketamine-dexmedetomidine anesthesia without altering the antinociceptive effects of butorphanol and buprenorphine in female C57BL/6J mice.