英文名称STAT6中文名称信号转导和转录激活因子6重组兔单克隆抗体别 名signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT. 研究领域肿瘤 发育生物学 信号转导 细胞凋亡 转录调节因子 表观遗传学 抗体来源Rabbit克隆类型Monoclonal克 隆 号7G4交叉反应Human, Mouse, 产品应用WB=1:500-2000 IP=1:20-100 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=2ug/Test ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量94kDa细胞定位细胞核 细胞浆 性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human STAT6: 亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.PubMedPubMed产品介绍The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
Subunit:
Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif.
Subcellular Location:
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Post-translational modifications:
Tyrosine phosphorylated following stimulation by IL-4 and IL-3.
Similarity:
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.