- ￥1900
- Biorigin
- BN40495R
- 2026年01月02日
- WB,
- Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 适应物种：
Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep,
- 应用范围：
WB,
- 抗体英文名：
TCL3/HOX11
- 规格：
100ul
| 英文名称 | TCL3/HOX11 |
| 中文名称 | T细胞白血病淋巴瘤蛋白3抗体 |
| 别 名 | Homeo box 11 (T cell leukemia 3 associated breakpoint homologous to Drosophila Notch); Homeo box 11 (T cell lymphoma 3 associated breakpoint); Homeobox 11; Homeobox protein Hox 11; Homeobox protein Hox-11; Homeobox TLX-1; Hox-11; Hox11; MGC163402; OTTHUMP00000020816; Proto oncogene TCL 3; Proto-oncogene TCL-3; RGD1563655; T cell leukemia homeobox protein 1; T cell leukemia lymphoma protein 3; T-all, included; T-cell acute lymphocytic leukemia, included; T-cell leukemia 3 gene; T-cell leukemia homeobox protein 1; T-cell leukemia, homeobox 1; T-cell leukemia/lymphoma protein 3; TCL 3 proto oncogene; TCL3; Tlx-1; TLX1; TLX1_HUMAN. |
| 研究领域 | 肿瘤 细胞生物 发育生物学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TCL3/HOX11:121-220/330 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. The Hox11 gene, termed an orphan homeobox gene, as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. The human Hox11 gene maps to chromosome 10q24 and has been implicated in the chromosomal translocation t(7;10)(q24;q11) that occurs in T-cell acute lymphoblastic leukemia (T-ALL). The t(7:10) translocation occurs between the Hox11 gene and the T-cell receptor (TCR) delta-chain gene and is a result of aberrant physiological recombinational events at the early stages of T-cell development. The Hox11 gene is normally expressed in the splanchnic anlage arising from the splanchnic mesoderm. Homozygous Hox11-deficient mice have no spleen, while all other splanchnic derivatives develop normally. Spleen development starts and proceeds normally in Hox11-deficient mice to a specific stage of embryogenesis, when the spleen anlage becomes fully absorbed. Function: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. Subcellular Location: Nucleus. DISEASE: Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. Similarity: Contains 1 homeobox DNA-binding domain. SWISS: P31314 Gene ID: 3195 Database links: Entrez Gene: 3195 Human Entrez Gene: 21908 Mouse Omim: 186770 Human SwissProt: P31314 Human SwissProt: P43345 Mouse Unigene: 89583 Human Unigene: 391203 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验乳腺癌病毒）本身并不含有癌基因，但是有促进基因，当感染宿主细胞后促进基因也可由于逆转录酶的作用而插入到宿主细胞DNA链中的原癌基因附近，引起正常的或突变的原癌基因激活并且过度表达，使宿主细胞转化。 人类T细胞白血病/淋巴瘤病毒I（human T－cell leukemia/lymhoma virus I，HTVL－1）是与人类肿瘤发生密切相关的一种RNA病毒，与主要流行于日本和加勒比地区的T细胞白血病/淋巴瘤有关。HTLV－1病毒与AIDS病毒一样，转化的靶细胞是CD4＋的T细胞亚群（辅助T
-1使TH细胞恶变为成熟T细胞白血病/淋巴瘤。结核杆菌和许多真菌的慢性感染常导致免疫缺陷。寄生虫感染如非洲慢性疟疾感染儿童其T细胞功能受抑制并可能与EB病毒引起的恶性肿瘤的发生有关。
-1）感染CD4+细胞。HIV和HTLV-1使TH细胞恶变为成熟T细胞白血病/淋巴瘤。结核杆菌和许多真菌的慢性感染常导致免疫缺陷。寄生虫感染如非洲慢性疟疾感染儿童其T细胞功能受抑制并可能与EB病毒引起的恶性肿瘤的发生有关。
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