一种有效的,选择性的 AT2 angiotensin II receptor 拮抗剂,IC50 值为 34 nM。
PD-123319 is a selective, nonpeptide AT2R antagonist (IC50 = 5.6 nM vs. 100 nM for AT1R). PD-123319 has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models.