一种高效、选择性和全效的 D1 样多巴胺受体 (D1/D5) 激动剂,对 D1 受体作用的 IC50 值为 10 nM。Dihydrexidine 具有高效的抗帕金森活性。Dihydrexidine 可以刺激 YAP 磷酸化。
Dihydrexidine is a dopamine D1 receptor agonist potentially for the treatment of schizotypal personality disorder. A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) has been shown to increase prefrontal perfusion in schizophrenia, and is safe and tolerated in patients with schizophrenia.