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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
NCI-H157
- 库存：
1x10^6/瓶
- 供应商：
上海酶研
- 肿瘤类型：
非小细胞肺鳞癌
- 细胞类型：
NCI-H157
- 品系：
NCI-H157
- 组织来源：
人非小细胞肺鳞癌细胞
- 相关疾病：
详询
- 物种来源：
人
- 免疫类型：
详询
- 细胞形态：
贴壁/悬浮
- 是否是肿瘤细胞：
是
- 器官来源：
人非小细胞肺鳞癌细胞
- 运输方式：
顺丰快递
- 年限：
5年
- 生长状态：
生长良好
- 规格：
T25
NCI-H157、NCI-H157、NCI-H157细胞、NCI-H157细胞、NCI-H157人非小细胞肺鳞癌细胞
Cell line name NCI-H157
Synonyms NCl-H157; NCI H157; H157; H-157; NCI-157; NCIH157DM; H157DM
Accession CVCL_0463
Resource Identification Initiative To cite this cell line use: NCI-H157 (RRID:CVCL_0463)
Comments Problematic cell line: Contaminated. NCI-H157 and NCI-H1264 have been shown to be identical.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00412.
Doubling time: 53 hours (Note=In RPMI 1640 + 10% FBS), 90 hours (Note=In ACL-3 + BSA) (PubMed=3940644); 20.8 hours (PubMed=29681454).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Sequence variations
Mutation; HGNC; 1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Homozygous (PubMed=30038707; DepMap=ACH-000921).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Heterozygous (PubMed=1311061; PubMed=12068308; DepMap=ACH-000921).
Mutation; HGNC; 11100; SMARCA4; Simple; p.Thr58Profs*36 (c.171del); Zygosity=Homozygous (DepMap=ACH-000921).
Mutation; HGNC; 11998; TP53; Simple; p.Leu35Phefs*8 (c.102_103insT) (c.103_104insT); Zygosity=Heterozygous (PubMed=10536175; PubMed=20557307; DepMap=ACH-000921).
Mutation; HGNC; 11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Heterozygous (PubMed=1311061; PubMed=10536175; PubMed=20557307; DepMap=ACH-000921).
Disease Lung squamous cell carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_VD88 (H157R)
Originate from same individual CVCL_3970 ! NCI-H1264
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-5802; CCRID=1101HUM-PUMC000113; CLS=300387
Markers:
Amelogenin X
CSF1PO 12
D2S1338 21,22
D3S1358 17,18
D5S818 10,13
D6S1043 17,24
D7S820 12
D8S1179 14,16
D12S391 20
D13S317 12
D16S539 12,13
D18S51 13,15
D19S433 11,13
D21S11 32
FGA 22,23
Penta D 2.2
Penta E 7
TH01 7,9
TPOX 6,12
vWA 15
Run an STR similarity search on this cell line
PubMed=6270685; DOI=10.1073/pnas.78.7.4591; PMCID=PMC319839
Cuttitta F., Rosen S.T., Gazdar A.F., Minna J.D.
Monoclonal antibodies that demonstrate specificity for several types of human lung cancer.
Proc. Natl. Acad. Sci. U.S.A. 78:4591-4595(1981)
PubMed=6272398; DOI=10.1126/science.6272398
Moody T.W., Pert C.B., Gazdar A.F., Carney D.N., Minna J.D.
High levels of intracellular bombesin characterize human small-cell lung carcinoma.
Science 214:1246-1248(1981)
PubMed=6148444; DOI=10.1093/jnci/73.4.801
Morstyn G., Russo A., Carney D.N., Karawya E., Wilson S.H. Jr., Mitchell J.B.
Heterogeneity in the radiation survival curves and biochemical properties of human lung cancer cell lines.
J. Natl. Cancer Inst. 73:801-807(1984)
PubMed=6713399
Rosen S.T., Mulshine J.L., Cuttitta F., Fedorko J., Carney D.N., Gazdar A.F., Minna J.D.
Analysis of human small cell lung cancer differentiation antigens using a panel of rat monoclonal antibodies.
Cancer Res. 44:2052-2061(1984)
PubMed=3940644
Brower M., Carney D.N., Oie H.K., Gazdar A.F., Minna J.D.
Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium.
Cancer Res. 46:798-806(1986)
PubMed=1311061
Mitsudomi T., Steinberg S.M., Nau M.M., Carbone D.P., D'Amico D., Bodner S.M., Oie H.K., Linnoila R.I., Mulshine J.L., Minna J.D., Gazdar A.F.
p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.
Oncogene 7:171-180(1992)
PubMed=1563005
Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.
Neuromedin B is present in lung cancer cell lines.
Cancer Res. 52:2732s-2736s(1992)
PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163
Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P., Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H., Harris C.C.
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)
PubMed=8626706; DOI=10.1074/jbc.271.19.11477
Quinn K.A., Treston A.M., Unsworth E.J., Miller M.-J., Vos M., Grimley C., Battey J., Mulshine J.L., Cuttitta F.
Insulin-like growth factor expression in human cancer cell lines.
J. Biol. Chem. 271:11477-11483(1996)
PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. Suppl. 24:32-91(1996)
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文献和实验*发表【中文论文】请标注：由上海酶研生物科技有限公司提供；
*发表【英文论文】请标注：From Shanghai EK-Bioscience Biotechnology Co., Ltd.
A Modified Protocol for Bisulfite Genomic Sequencing of Difficult Samples
, are RARB2 -transfectants that were established in our laboratory (21 ). MM-1 was also established in our laboratory (6 ). NCI-H23, NCI-H82, NCI-H125, NCI-H157, NCI-H520, and NCI-H596 were supplied by Dr. Adi Gazdar (NCI, NIH, Bethesda, MD). NBE-E6 E7 (22
MDA-MB-157 人乳腺癌细胞 MDA-MB-231 人乳腺癌细胞 MDA-MB-435s 人乳腺癌细胞 MDA-MB-453 人乳腺癌细胞 MG-63 人骨肉瘤细胞 Mo7e 人巨细胞白血病细胞(B类) MOLT-4 人淋巴细胞白血病细胞 NCI-H157 人非小细胞肺腺癌 NCI-H209 人小细胞肺癌 NCI-H446 人小细胞肺癌 NTERA-2 人恶性多发性畸胎瘤细胞 PA-1 人卵巢畸胎瘤细胞 ANC-1 人胰腺癌细胞 PC-3
Science 子刊揭露遗传性肺癌亚型，我们离肺癌精准医疗还有多远？
我国是癌症大国，而肺癌，占我国每年新发癌症的 20%。据统计，2020 年，中国有 71 万人因肺癌死亡，接近死亡人数第二名肝癌以及第三名胃癌之和，肺癌对我国，乃至全球人民的健康危害可见一斑。 长久以来，中国肺癌的高发被归咎于庞大的吸烟人群以及为人诟病的空气质量，而抽烟被认为是「小细胞肺癌」（SCLC）的主要致病因素，80% 的 SCLC 与抽烟有关。但与乳腺癌等遗传因素被广泛研究的癌症不同，学术界对 SCLC 的遗传诱因并未有系统化的探究。图片来源：Science Translational
技术资料