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- 详细信息
- 文献和实验
- 技术资料
- 英文名:
NCI-H526
- 库存:
1x10^6/瓶
- 供应商:
上海酶研
- 肿瘤类型:
肺癌
- 细胞类型:
NCI-H526
- 品系:
NCI-H526
- 组织来源:
小细胞肺癌细胞
- 相关疾病:
详询
- 物种来源:
Human
- 免疫类型:
详询
- 细胞形态:
贴壁/悬浮
- 是否是肿瘤细胞:
是
- 器官来源:
小细胞肺癌细胞
- 运输方式:
顺丰快递
- 年限:
5年
- 生长状态:
生长良好
- 规格:
瓶
NCI-H526细胞系;H526细胞株;NCI-H526细胞;H526细胞;NCI-H526小细胞肺癌细胞
Cell line name NCI-H526
Synonyms H526; H-526; NCIH526
Accession CVCL_1569
Resource Identification Initiative To cite this cell line use: NCI-H526 (RRID:CVCL_1569)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
PubMed=1312696
D'Amico D., Carbone D.P., Mitsudomi T., Nau M.M., Fedorko J., Russell E., Johnson B., Buchhagen D.L., Bodner S.M., Phelps R.M., Gazdar A.F., Minna J.D.
High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.
Oncogene 7:339-346(1992)
PubMed=1320893; DOI=10.1159/000163712
Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M., Carney D.N., Bepler G., Roebroek A.J.M., van de Ven W.J.M., Burbach J.P.H.
Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines.
Pathobiology 60:136-142(1992)
PubMed=1565469
Bodner S.M., Minna J.D., Jensen S.M., D'Amico D., Carbone D.P., Mitsudomi T., Fedorko J., Buchhagen D.L., Nau M.M., Gazdar A.F., Linnoila R.I.
Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.
Oncogene 7:743-749(1992)
PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. Suppl. 24:32-91(1996)
PubMed=8806103; DOI=10.1002/jcb.240630516
Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M., Ihde D.C., Gazdar A.F.
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
J. Cell. Biochem. Suppl. 24:210-217(1996)
PubMed=10037197
Tang X.X., Brodeur G.M., Campling B.G., Ikegaki N.
Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma.
Clin. Cancer Res. 5:455-460(1999)
PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)
PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)
PubMed=17426248; DOI=10.1158/1541-7786.MCR-06-0367
Olejniczak E.T., Van Sant C., Anderson M.G., Wang G., Tahir S.K., Sauter G., Lesniewski R., Semizarov D.
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.
Mol. Cancer Res. 5:331-339(2007)
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文献和实验*发表【中文论文】请标注:由上海酶研生物科技有限公司提供;
*发表【英文论文】请标注:From Shanghai EK-Bioscience Biotechnology Co., Ltd.
Science 子刊揭露遗传性肺癌亚型,我们离肺癌精准医疗还有多远?
我国是癌症大国,而肺癌,占我国每年新发癌症的 20%。据统计,2020 年,中国有 71 万人因肺癌死亡,接近死亡人数第二名肝癌以及第三名胃癌之和,肺癌对我国,乃至全球人民的健康危害可见一斑。 长久以来,中国肺癌的高发被归咎于庞大的吸烟人群以及为人诟病的空气质量,而抽烟被认为是「小细胞肺癌」(SCLC)的主要致病因素,80% 的 SCLC 与抽烟有关。但与乳腺癌等遗传因素被广泛研究的癌症不同,学术界对 SCLC 的遗传诱因并未有系统化的探究。图片来源:Science Translational
MDA-MB-157 人乳腺癌细胞 MDA-MB-231 人乳腺癌细胞 MDA-MB-435s 人乳腺癌细胞 MDA-MB-453 人乳腺癌细胞 MG-63 人骨肉瘤细胞 Mo7e 人巨细胞白血病细胞(B类) MOLT-4 人淋巴细胞白血病细胞 NCI-H157 人非小细胞肺腺癌 NCI-H209 人小细胞肺癌 NCI-H446 人小细胞肺癌 NTERA-2 人恶性多发性畸胎瘤细胞 PA-1 人卵巢畸胎瘤细胞 ANC-1 人胰腺癌细胞 PC-3
)等,其中ATCC不仅是美国也世界最大的细胞库。ATCC下属有一组协作实验室和一个由众多专家组成的咨询委员会。ATCC也是美国国立癌症研究所(NCI)和美国卫生研究所中(NIH)的资源库,尤与NCI有密切的关系。ATCC也是世界卫生组织WHO的国际培养细胞文献中心。ATCC现液氮冻存有3200个已经过鉴定的细胞系(1992),其中包括来自正常人和各种疾病患者的皮肤成纤维细胞系;和来自不同物种的近75个杂交瘤细胞株。ATCC接纳来自世界各国已经鉴定的细胞予以贮存,同时也向世界各国的研究者或实验室免费提供研究用细胞
技术资料







