N-Hexanoyl-NBD-glucosylceramide
CAS号:94885-03-7
规格:1 mg
纯度:≥98%
品牌:Matreya, LLC
货号:M-1622
分子量:737.9
分子式:C36H59N5O11
保存温度:-20
Sales class:Normal
Formulation:A neat solid
Item Synonyms:N-C6:0-NBD-beta-D-Glucosylsphingosine|N-C6:0-NBD-Glucosylceramide
Item origin:Semi-synthetic|Animal/Bovine
Availability status:Worldwide
Application Notes:This high purity fluorescent product is ideal for the identification of glucocerebrosides in samples and biological systems.1 7-nitrobenzofurazan (NBD) has been shown to have only a small influence on lipid adsorption into cells and cellular membranes. This fluorescent analog of natural glucosylceramide is comparable to C6:0-glucosylceramide in many biological functions.2 This cerebroside product is a glycosphingolipid containing a glucose attached to a ceramide (glucocerebroside) acylated with a C6:0-NBD fatty acid. Glucosylceramide is a major constituent of skin lipids where it has an important role in lamellar body formation and in maintaining the water permeability barrier. Glucocerebroside is very important due to its function as the biosynthetic precursor of lactosylceramide and from there of most of the neutral oligoglycolipids and gangliosides. Glucocerebroside is the only glycosphingolipid that is found in plants, fungi, and animals and is one of the most abundant glycosphingolipids in plants. Due to the relatively high melting point of cerebrosides (much greater than physiological body temperature) they have a para-crystalline structure. Glucocerebrosides tend to be concentrated in the outer leaflet of the plasma membrane in lipid rafts. It has been reported that glucocerebrosides are essential for the activity of tyrosinase (a key enzyme in melanin biosynthesis), to elicit defense responses in plants, and to help the plasma membrane in plants to withstand stresses brought about by cold and drought. In Gaucher’s disease glucocerebrosides accumulate in the spleen, liver, lungs, bone marrow, and brain due to a deficiency of the enzyme glucocerebrosidase.3 This accumulation of glucocerebroside has been associated with chemotherapy resistance. Glucocerebroside has been shown to be able to modulate membrane traffic along the endocytic pathway.4
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