Ceramide trihexosides (top spot)
CAS号:
规格:500 µg
纯度:≥98%
品牌:Matreya, LLC
货号:M-1513
分子量:1052.4
分子式:C54H101NO18 (stearoyl)
保存温度:-20
Sales class:Normal
Formulation:A neat solid
Item Synonyms:CTH with non-hydroxy fatty acid side chain
Item origin:Animal/Porcine RBC
Availability status:Worldwide
Application Notes:Ceramide trihexoside is a glycosphingolipid found mostly in mammalian cell membranes. It is involved in cellular signaling and has been identified as a receptor for various toxins including shiga toxins and shiga-like toxins.1 Some toxins, such as veratoxins from Escherichia coli, require specific fatty acids on the ceramide portion of CTH to show affinity in binding. An accumulation of CTH in the cellular membranes due to a lack of alpha-galactosidase to convert it into lactosyl ceramide results in Fabry disease.2 This product can be used as an excellent standard for the identification of CTH in Fabry disease by HPLC3 and mass spectrometry.4 An inability to convert CTH to globoside due to mutations in the gene sequence leads to the Pk Blood Group Phenotype. It appears that under certain conditions CTH can enhance anticoagulant activity. CTH has also been studied as a tool to investigate lymphocyte activation.5
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