ITGB5 is a Protein Coding gene. Integrin beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Integrin beta-5 acts as a receptor for adenovirus type C. Diseases associated with ITGB5 include villous adenocarcinoma and localized scleroderma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include receptor activity and integrin binding. An important paralog of this gene is ITGB4.