Inhibitor of nuclear factor kappa-B kinase subunit beta encoded by IKBKB phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. Inhibitor of nuclear factor kappa-B kinase subunit beta itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.