关键词:MRP1抗体;多药耐药相关蛋白1抗体;多药耐药相关蛋白1;Multidrug resistance-associated protein 1; Leukotriene C(4) transporter; LTC4 transporter; ATP-binding cassette sub-family C member 1;ABP59326
ABCC1 (ATP Binding Cassette Subfamily C Member 1) is a Protein Coding gene. Diseases associated with ABCC1 include Dubin-Johnson Syndrome and Microsporidiosis. Among its related pathways are Doxorubicin Pathway, Pharmacokinetics and CDK-mediated phosphorylation and removal of Cdc6. The protein encoded by ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts.