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ruthenium tetroxide
Useful as a staining agent for electron microscopy of polymers, as well as a fixative for biological samples. Ruthenium tetroxide penetrates tissue very slowly, reacting strongly with proteins, glycogen and monosaccharides.
Ruthenium tetroxide can be used as an even more aggressive form of staining for the study of polymers by TEM than osmium tetroxide.
Supplied in pre-scored ampoules each with its own ampoule cracker.
Recommended Storage: 4°C in refrigerator
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文献和实验Osmium Tetroxide Modification and the Study of DNA-Protein Interactions
Osmium tetroxide is an evil-smelling chemical used as a fixative in electron microscopy that can also be used to modify thymidine residues within DNA (1 ,2 ). The ability of osmium tetroxide to modify DNA is very sensitive to DNA conformation
四氧化锇（ OrO4 ）为无色结晶，一般常称为锇酸，实际是不正确的。其气体具有刺激性气味，能引起粘膜发炎。溶解于水、醇等。很早以来就作为光学显微镜用的生物材料的固定剂而被应用。因为能将生物的微细构造固定得比较接近于生活时的状态，所以也用作电子显微镜用的材料固定剂。现在广泛用于戊二醛固定后的生物材料的固定。
Chemical probing of nucleic acids is a powerful and versatile approach to the detection and analysis of the structural and functional complexity of nucleic acids (1 ). Secondary structures of native DNA and RNA as well as ligandinduced
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