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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
UK-453061
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
473921-12-9
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 1 mg | 产品价格： | ￥428.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥983.0 |
| 规格： | 10 mg | 产品价格： | ￥1560.0 |
| 规格： | 25 mg | 产品价格： | ￥3120.0 |
| 规格： | 50 mg | 产品价格： | ￥4680.0 |
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Lersivirine
CAS No. : 473921-12-9
MCE 国际站：Lersivirine
产品活性：Lersivirine (UK-453061) 是非核苷逆转录的抑制剂 (NNRTI; IC50=119 nM)，对 NNRTI 耐药病毒具有优异的抑制效果。Lersivirine 对野生型人类免疫缺陷病毒 (HIV) 和临床相关 NNRTI 耐药菌株显示出强大的抗逆转录病毒活性。
研究领域：Anti-infection
作用靶点：HIV | Reverse Transcriptase
In Vitro: Lersivirine demonstrates excellent activity against large panels of wild type and drug-resistant HIV consistent with the encouraging profile demonstrated against the isolated RT enzymes.
In Vivo: Lersivirine (oral gavage; 0, 150, 350, and 500 mg/kg; once daily; gestation days 6 to 17, followed by cesarean section on gestation day 18. ) allows induction of hepatic metabolizing enzymes at the first 2 days at 250 mg/kg, after which the dose is increased to 500 mg/kg/day in Mated Crl:CD1(ICR) mice. Lersivirine leads to skeletal variations which related to delayed development and decreased fetal ossifications.
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