M-31850,281224-40-6

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M-31850

CAS No. : 281224-40-6

MCE 国际站：M-31850

产品活性：M-31850 是一种有效，选择性和竞争性的 β-己糖胺酶 (β-hexosaminidase (Hex)) 抑制剂，对人 HexA 和 HexB 的 IC₅₀ 分别为 6.0 µM 和 3.1 µM。M-31850 还以 K_i 为 2.5 μM 来竞争性抑制 β-N-acetyl-D-hexosaminidase OfHex2。

研究领域：Others

作用靶点：Others

In Vitro: M-31850 shows some activity towards Jack Bean Hex (JBHex) and bacterial Hex from Streptomyces plicatus (SpHex) (IC₅₀ of 280 μM and >500 μM for JBHex and SpHex, respectively).
?M-31850 produces a dose dependent increase in MUG hydrolysis (Hex S levels) in lysates from treated infantile Sandhoff disease (ISD) cells.
?M-31850 increases the half-life of the mutant Hex A from Adult forms of Tay-Sachs (ATSD) cells more than two-fold at 44° C, relative to the enzyme heated in the presence of DMSO. M-31850 acts as a classic competitive inhibitor of Hex (K_m increases and V_max is unaffected by increasing amounts of M-31850), with a K_i of 0.8 μM.

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