Itaconate-alkyne,2454181-83-8

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Itaconate-alkyne

CAS No. : 2454181-83-8

MCE 国际站：Itaconate-alkyne

产品活性：Itaconate-alkyne (ITalk) 是一种特异性的生物正交探针，用于定量和定位活细胞中衣康酸 (Itaconation) 化学蛋白质组学分析。Itaconate-alkyne 是衣康酸的功能类似物，具有相似的抗炎作用，并可以标记衣康酸的真正靶标。Itaconate-alkyne 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

研究领域：Others

作用靶点：Others

In Vitro: Itaconate-alkyne (ITalk; 0.005, 0.01, 0.05, 0.1, 0.5, 1, 5, 10 mM; 0-4 hours) has the concentration- and time-dependent labeling in the lysates of Raw264.7 cells.
Itaconate-alkyne (100 μM; for 4 hours) significantly increases the protein level of NRF-2 in LPS (100 ng/mL)-stimulated Raw264.7 cells and significantly inhibits lactate production in LPS-stimulated Raw264.7 cells. Itaconate-alkyne significantly inhibits the secretion of interlukin-1β (IL-1β) in LPS-timulated Raw264.7 cells.
Itaconate-alkyne (100 μM; for 12 hours) does not affect the cell viability of Raw264.7 cells.
Itaconate-alkyne can capture itaconate targets including DNA damage-binding protein 1 (DDB1), Gelsolin (GSN), ATP-citrate synthase (ACLY) and Adenylate kinase 2 (AK2) in inflammatory macrophages.

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