BMS-587101,509083-77-6

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BMS-587101

CAS No. : 509083-77-6

MCE 国际站：BMS-587101

产品活性：BMS-587101 是一种有效的具有口服活性的 leukocyte function associated antigen-1 (LFA-1) 拮抗剂。BMS-587101 具有抗炎作用，可用于类风湿关节炎的研究。

研究领域：Cytoskeleton

作用靶点：Integrin

In Vitro: BMS-587101 is a moderately potent inhibitor of LFA-1-mediated T-cell proliferation, with an IC₅₀ of 20 nM in human HUVEC cells. BMS-587101 inhibits LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production.
?In mouse splenocytes and a mouse ICAM-1 expressing cell lines, bEND, BMS-587101 shows inhibitory activities, with an IC₅₀ of 150 nM.

In Vivo: In the mouse ovalbumin-induced lung inflammation model, BMS-587101 (0.1 mg/kg, 1.0 mg/kg, and 10 mg/kg; po.; twice a day) treatment significantly inhibits eosinophil accumulation.

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