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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
78967-07-4
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥770.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥700.0 |
| 规格： | 10 mg | 产品价格： | ￥1200.0 |
| 规格： | 25 mg | 产品价格： | ￥2500.0 |
| 规格： | 50 mg | 产品价格： | ￥3800.0 |
| 规格： | 100 mg | 产品价格： | ￥5800.0 |
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Mofezolac
CAS No. : 78967-07-4
MCE 国际站：Mofezolac
产品活性：Mofezolac，一种非甾体类抗炎剂 (NSAID)，是一种选择性，可逆和具有口服活性的 COX-1 抑制剂，IC50 为 1.44 nM。Mofezolac 对 COX-2 的抑制活性较弱 (IC50 为 447 nM)。Mofezolac 可缓解疼痛并具有抗炎活性。
作用靶点：COX
In Vitro: Mofezolac inhibits platelet aggregation with an IC50 of 0.45 μM in human platelet rich plasma (hPRP) assay.
Mofezolac slightly increase Bortezomib cytotoxic effect on multiple myeloma (MM) cell lines (NCI-H929 and RPMI-8226) and affects MM cell cycle and apoptosis when co-administered with the proteasome inhibitor Bortezomib.
In Vivo: Mofezolac (1-30 mg/kg; oral administration; once) treatment results in the suppression of writhing induced by the intraperitoneal injection of phenyl-p-benzoquinone in mice.
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