CGP 78608,1135278-54-4

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CGP 78608 hydrochloride

CAS No. : 1135278-54-4

MCE 国际站：CGP 78608 hydrochloride

产品活性：CGP 78608 hydrochlorid 是 NMDA 受体甘氨酸结合位点的一种高效选择性拮抗剂，IC₅₀ 为 6 nM。CGP 78608 作为 GluN1/GluN3A 介导的甘氨酸电流的增强剂，EC₅₀ 值为 26.3 nM。具有抗惊厥活性。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：iGluR

In Vitro: CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites.
CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity.

In Vivo: CGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice.

相关产品：Corticosterone  |  D-AP5  |  Dizocilpine maleate  |  NMDA  |  L-Glutamic acid  |  Evans Blue  |  CNQX  |  Kynurenic acid  |  Glycine  |  NBQX  |  Cycloleucine  |  L-Phenylalanine  |  Quinolinic acid  |  Memantine hydrochloride  |  Ifenprodil tartrate  |  D-Cycloserine  |  DNQX  |  Ro 25-6981 Maleate  |  Ibotenic acid  |  (-)-Huperzine A  |  Decanoic acid  |  Crocetin  |  Tat-NR2B9c TFA  |  Topiramate  |  Piracetam  |  24-Hydroxycholesterol  |  Naspm trihydrochloride  |  Tacrine hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds