Ivacaftor-d9依伐卡托 d9,1413431-07

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Ivacaftor-d9

CAS No. : 1413431-07-8

MCE 国际站：Ivacaftor-d9

产品活性：Ivacaftor-d₉ 是一种有效的 CFTR 调节剂，在 G551D/F508del HBE 细胞中 CFTR 增强的 EC₅₀ 值为 255 nM。Ivacaftor- d9 作为一种具有口服活性和改良的 Ivacaftor 氘化物用于囊性纤维化研究。

研究领域：Membrane Transporter/Ion Channel

作用靶点：CFTR

In Vivo: In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters C_max, AUC_{0-24 hr}, C_24hr and t_1/2 of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters C_max, AUC_{0-24 hr}, C_24hr and t_1/2 of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

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