β-Glucuronidase-IN-1,484006-66

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

β-Glucuronidase-IN-1

CAS No. : 484006-66-8

MCE 国际站：β-Glucuronidase-IN-1

产品活性：β-Glucuronidase-IN-1 是强效的，选择性，非竞争性和具有口服活性的 E. coli β-葡萄糖醛酸酶 (β-glucuronidase) 抑制剂，针对 E. coli β-葡萄糖醛酸酶的 IC₅₀ 和 K_i 值分别为 283 nM 和 164 nM。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: β-Glucuronidase-IN-1 (Inhibitor 1) (0.01-100 μM) inhibits E. coli β-glucuronidase activity as a dose-dependent manner and exhibits an IC₅₀ and a K_i value with 283 nM and 164 nM, respectively.
β-Glucuronidase-IN-1 (100 μM; 24-72 hours) maintains potent efficacy in living bacterial cells (EC₅₀=17.7 nM), it does not affect bacterial cell growth under aerobic or anaerobic conditions or killing mammalian epithelial cells.

In Vivo: β-Glucuronidase-IN-1 (oral gavage; 10 μg; twice per day; 11 days) protects the mouse GI epithelium from CPT-11–induced damage and protects the glandular structure of CPT-11-treated intestinal tissues.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Anti-Cancer Compound Library  |  Antibacterial Compound Library  |  Highly Selective Inhibitors Library  |  Rapamycin  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Dexamethasone  |  Puromycin dihydrochloride  |  Dimethyl sulfoxide  |  Staurosporine  |  Actinomycin D  |  G-418 disulfate  |  Etoposide  |  5-Azacytidine  |  Nigericin sodium salt  |  Brefeldin A  |  Estradiol  |  CCCP  |  Ionomycin  |  Resveratrol  |  Hygromycin B  |  Tunicamycin  |  Mitomycin C  |  Everolimus  |  Doxycycline hyclate  |  Tacrolimus  |  Methotrexate  |  Neomycin sulfate  |  Acetaminophen  |  Streptozotocin  |  Anisomycin  |  Cholesterol

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds