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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1394011-91-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1060.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥400.0 |
| 规格： | 5 mg | 产品价格： | ￥1000.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 25 mg | 产品价格： | ￥3000.0 |
| 规格： | 50 mg | 产品价格： | ￥4800.0 |
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UC2288
CAS No. : 1394011-91-6
MCE 国际站：UC2288
产品活性：UC2288 是一种新型的、具有细胞通透性和口服活性的 p21 衰减试剂 (对 p21 具有相对选择性活性)，基于索拉非尼 (HY-10201) 的结构合成。UC2288 在不依赖 p53 的情况下下调 p21 mRNA 的表达，降低 p21 蛋白水平，对 p21 蛋白的稳定性影响很小。UC2288 对VEGFR2 和 Raf 激酶没有抑制作用，即使在 10 μM。
研究领域：Apoptosis
作用靶点：MDM-2/p53
In Vitro: UC2288 (0-10 μM; 24 hours) decreases p21 protein level, but has no effects on other proteins.
UC2288 (0-10 μM; 24 hours) decreases p21 mRNA expression transcriptionally or post-transcriptionally but independently of p53.
In Vivo: UC2888 (oral gavage; 15 mg/kg; 3 times a week; 4 weeks) co-treatment with imetelstat significantly suppresses tumor growth?and does not effect mice weight.
UC2288 (intraperitoneal?injection; 10 mg/kg; 4 times in 7 days) attenuates MPTP-induced behavioral impairment, prevents activation of MAPK pathway in the MPTP-treated mice brain. MPTP treatment raises TNF-α, IL-6 and IL-1β levels in MPTP treated mice brain, but UC2288 signicantly decreases MPTP-induced TNF-α, IL-6 levels, but IL-1β is not decreased in brain.
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文献和实验9973qu6zrY//cRnNGFQHjYSpTFqYzcVwfcGpxKTCq/A/t6LYv32EgQiSd5LGiKKERGICEQEIgL7AQIidhkZ71alO122/CWbMm2qtbXJw4OUs08//bT9w1f/3v7xf37dHnn4UU3oEzEVqV61co3dcded9vnPfs5uvWmBzTn+eHv5+Rdsy7q1du6559oV3/2ezZs71558/Alpmev28K9+adu7um3jls2YJ9stt91qc045ya677lo7/PDp
tkwggxOgYxdvEj687uNt8dWwWVYV2b9dxboxU7Fq4EyUvr4G9XJG91xREJIPdrhkmwVKsiD4/XSDp68KjDu1R+Ni2pIRqoJmwcMwgQxBgIWPDLGNvAgmkFEIqCJf7Z7oU6g4+pq3RmGhUTDoipkLb+JCH1vseeSNeg2yp8pis7RYj3MWtSCZocj84Lx/KNpMm4KJparjSP9CkkYkVSbGgzKBdEggFQ9M0yEtnjITYAIpTEADRbpMwcyJbUMFj7+jaeiZIDcC4P71
of protein transport properties: Diffusion tensors, specific volume, and hydration. Biophys. J. 91:1591‐1603. Balbo, A., Minor, K.H., Velikovsky, C.A., Mariuzza, R., Peterson, C.B
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