RO0711401,714971-87-6

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RO0711401

CAS No. : 714971-87-6

MCE 国际站：RO0711401

产品活性：RO0711401 是一种选择性的具有口服活性的 mGlu1 受体的正变构调节剂，EC₅₀ 为 56 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mGluR

In Vivo: RO0711401 (10 mg/kg; s.c.; once) causes a long-lasting improvement in motor performance, which is maintained to the same extent at least for 6 days.
Systemic injection of RO0711401 is shown to reduce the frequency of spike-and-wave discharges in a rat model of absence epilepsy, and to improve motor signs in autoimmune encephalomyelitis (EAE) mice.

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