DDR1-IN-6,2416021-47-9

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DDR1-IN-6

CAS No. : 2416021-47-9

MCE 国际站：DDR1-IN-6

产品活性：DDR1-IN-6 是选择性的盘状结构域受体家族成员 1 (DDR1) 抑制剂，IC₅₀ 为 9.72 nM。DDR1-IN-6 抑制 DDR1b (Y513) 自磷酸化，IC₅₀ 为 9.7 nM。DDR1-IN-6 具有抗癌活性。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：Discoidin Domain Receptor

In Vitro: DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC₅₀=13 nM).
DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC₅₀=3 μM).
DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC₅₀=5.7 μM of 3 days; IC₅₀=2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC₅₀>30 μM of 3 days; IC₅₀>30 μM of 6 days).

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