FIIN-1,1256152-35-8

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FIIN-1

CAS No. : 1256152-35-8

MCE 国际站：FIIN-1

产品活性：FIIN-1 是一种有效的，不可逆的选择性 FGFR 抑制剂。FIIN-1 与 FGFR1/2/3/4 和 Flt1/4 结合，K_d 分别为 2.8/6.9/5.4/120 nM 和 32/120 nM。FIIN-1 抑制 FGFR1/2/3/4 的 IC₅₀ 分别是 9.2，6.2，11.9 和 189 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：FGFR

In Vitro: FIIN-1 binds to BLK, ERK5, KIT, MET, PDGFRB and VEGFR2 with K_ds of 65 nM, 160, 420, 1000, 480 and 210 nM, respectively. The IC₅₀s for Blk and Flt1 are 381 nM and 661 nM respectively.
FIIN-1 (14 nM-46 μM; 72 hours) inhibits proliferation of FGF signaling-sensitive cancer cell lines.
FIIN-1 (20 nM) inhibits iFGFR1 autophosphorylation and its downstream Erk1/2 almost completely.

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