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- 2025年12月05日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- 规格：
10 mM * 1 mL///1 mg
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E7090
CAS No. : 1622204-21-0
MCE 国际站：E7090
产品活性：E7090 是一种有效的，具有口服活性的选择性 FGFR 抑制剂，对 FGFR1/FGFR2/FGFR3/FGFR4 的 IC50 值分别为 0.71 nM、0.50 nM、1.2 nM 和120 nM。
研究领域：Protein Tyrosine Kinase/RTK
作用靶点：FGFR
In Vitro: E7090 inhibits the growth of SNU-16, human gastric cancer cell line harboring FGFR2 amplification with an IC50 value of 3 nM.
E7090 inhibits SNU-16 cell proliferation with an IC50 value of 5.7 nM.
E7090 inhibits proliferation of human cancer cell lines harboring various types of FGFRs gene abnormalities such as amplification, mutation, or translocation in vitro, which are confirmed by the inhibition of FGFR signaling.
E7090 has interaction kinetics with FGFR1 kinases intermediate between those of the two representative inhibitors, and the residence time of E7090 succinate is 19 minutes.
In Vivo: Pharmacodynamics analysis reveals that E7090 inhibits phosphorylation of FGFRs in SNU-16 xenograft tumors in a dose-dependent manner.
E7090 (6.25-50 mg/kg, orally, once daily) treatment prolongs survival in a 4T1 mouse lung metastasis model.
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文献和实验Purification of dnEBNA-1/Soft from E. coli BL21 LysS
Inoculate 2ml of 5ml o/n culture of either p3133 (empty vector pET11a)or p3134 (dnEBNA-1/Soft)in E.coli BL21 LysS per 0.5L LB+ ampicillin (grow two 0.5L cultures of each) Incubate ~2hrs 37℃250rpm until OD600 = 0.4-0.6 Induce with 5ml 100mM ITPG
Optimizing E. coli-Based Membrane Protein Production Using Lemo21(DE3) and GFP-Fusions
Optimizing the conditions for the overexpression of membrane proteins in E . coli and their subsequent purification is usually a laborious and time-consuming process. Combining the Lemo21(DE3) strain, which conveniently allows to identify
浅析染色质免疫沉淀（ChIP）技术在 DNA 与蛋白质相互作用研究中的重要性
-wide analysis of protein binding in mammalian cells. Curr Protoc Mol Biol, 2007. Chapter 21: p. Unit 21 13. [24] Metzger, E., et al., LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature, 2005. 437(7057): p. 436
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