BMS-1166-N-piperidine-CO-N-pip

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BMS-1166-N-piperidine-CO-N-piperazine

CAS No. : 2447066-14-8

MCE 国际站：BMS-1166-N-piperidine-CO-N-piperazine

产品活性：BMS-1166-N-piperidine-CO-N-piperazine 包含靶蛋白 PD-1/PD-L1 配体和 PROTAC linker。BMS-1166-N-piperidine-CO-N-piperazine 可用于合成 PROTAC PD-1/PD-L1 降解剂 (HY-131183)。PROTAC PD-1/PD-L1 degrader-1 抑制 PD-1/PD-L1 相互作用，IC₅₀ 值为 39.2 nM。

研究领域：PROTAC

作用靶点：Target Protein Ligand-Linker Conjugates

In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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