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- 2025年12月05日
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- 详细信息
- 询价记录
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
GB002; PK10571
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1240.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥515.0 |
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥1800.0 |
| 规格： | 25 mg | 产品价格： | ￥3200.0 |
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Seralutinib
CAS No. : 1619931-27-9
MCE 国际站：Seralutinib
产品活性：Seralutinib (GB002) 是一个可吸入的 PDGFRα 和 PDGFRβ 激酶抑制剂。Seralutinib 同样抑制 CSF1R 和 c-KIT，IC50 分别为 8 nM 和 14 nM。Seralutinib (GB002) 可用于肺动脉高压的研究。
研究领域：Protein Tyrosine Kinase/RTK
In Vivo: Seralutinib (GB002) (two-week treatment, delivered by inhalation) significantly reduces right ventricular systolic pressure and mean pulmonary artery pressure. Hemodynamic changes are accompanied by reduced pulmonary arteriole muscularization and restoration of BMPR2 protein expression in the lung lobes in Seralutinib (GB002)-treated animals. Seralutinib (GB002) is well tolerated.
Seralutinib-mediated inhibition of lung PDGFRα/β phosphorylation in healthy Sprague Dawley rats immediately post inhalation.
Seralutinib dose- and time-dependently induces lung BMPR2 protein expression.
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