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4°C, stored under nitrogen
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货期：1-2天
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MedChemExpress LLC
- 规格：
1 mg
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DPM-1001 trihydrochloride
MCE 国际站：DPM-1001 trihydrochloride
产品活性：DPM-1001 trihydrochloride 是一种有效的，特异性的，具有口服活性的，且非竞争性的蛋白酪氨酸磷酸酶 (PTP1B) 抑制剂，其 IC50 为 100 nM。DPM-1001 trihydrochloride 是特异性 PTP1B 抑制剂 MSI-1436 (IC50=600 nM) 的类似物。DPM-1001 trihydrochloride 具有抗糖尿病特性。
研究领域：Metabolic Enzyme/Protease
作用靶点：Phosphatase
In Vitro: DPM-1001 trihydrochloride inhibits the short form of PTP1B reversibly, whereas PTP1B(1–405) remained inactive over an extended period of time. DPM-1001 is against PTP1B(1–405) with no pre-incubation, the IC50 value for PTP1B(1–405) is 600 nM. However, after a 30-min pre-incubation, the potency is improved to 100 nM. In contrast, there is no obvious time-dependent change in the IC50 value for PTP1B(1–321).
In Vivo: DPM-1001 trihydrochloride (oral or intraperitoneal administration; 5 mg/kg; once daily; 50 days) inhibits diet-induced obesity in mice by improving insulin and leptin signaling. DPM-1001 trihydrochloride-treated, high-fat diet-fed mice starts losing weight within 5 days of treatment. The weight loss continues for approximately 3 weeks, after which no further decrease in body weight is observed.
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文献和实验Detection and Measurement of Radioactivity
undergoing 2.22 x 10^12 atomic disintegrations per minute (DPM). A milliCurie (mCi) of a radioisotope undergoes 2.22 x 109 DPM, and a microCurie produces 2.22 x 10^6 DPM. Since 1975, the becquerel (Bq) has replaced the Curie as the preferred international
in the unabsorbed sample (TC). From Leslie and Hansen (1991). 3) For each sample tested, lyophilize 2 aliquants of 200,000 dpm of radiolabeled protein and 1 aliquant of 100,000 dpm in 1.5 ml microcentrifuge tubes. The samples of 200,000 dpm will be used
and convenient means for preparation of highly labeled DNA (>109dpm/µg) for use diverse procedures in molecular biology, such as various types of hybridization analyses [3-6]. Either dATP or dCTP could be used with the kit as a radioactive precursor.Now, non
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