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- 2025年07月10日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
TAK-935; OV935
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1760.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥727.0 |
| 规格： | 5 mg | 产品价格： | ￥1600.0 |
| 规格： | 10 mg | 产品价格： | ￥2600.0 |
| 规格： | 25 mg | 产品价格： | ￥5000.0 |
| 规格： | 50 mg | 产品价格： | ￥7500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Soticlestat
CAS No. : 1429505-03-2
MCE 国际站：Soticlestat
产品活性：Soticlestat (TAK-935; OV935) 是一种首创的，有效的，选择性的，具有口服活性的胆固醇 24-羟化酶 (cholesterol 24-hydroxylase, CH24H) 抑制剂。Soticlestat 可用于癫痫综合征的研究。
研究领域：Metabolic Enzyme/Protease
作用靶点：Cytochrome P450
In Vitro: Soticlestat inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50 of 4.5 nM.
In Vivo: Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus.
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