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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Triacetyloleandomycin
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥ |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1900.0 |
| 规格： | 5 mg | 产品价格： | ￥5300.0 |
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Troleandomycin
CAS No. : 2751-09-9
MCE 国际站：Troleandomycin
产品活性：Troleandomycin (Triacetyloleandomycin) 是一种大环内酯类抗生素，是选择性的 CYP3A 抑制剂。Troleandomycin 是具有口服活性的、可用于哮喘研究的口服皮质类固醇。
研究领域：Metabolic Enzyme/Protease | Anti-infection
作用靶点：Cytochrome P450 | Bacterial
In Vitro: Troleandomycin markedly inhibits 6β-hydroxylation of testosterone, 25- and 26-hydroxylations of 5β-cholestane-3α,7α,12α-triol and 23R-, 24R-, 24S-, and 27-hydroxylations of 5β-cholestane-3α,7α,12α,25-tetrol in both recombinant CYP3A4 and microsomes, but IC50 values for microsomes are somewhat higher than those for recombinant CYP3A4.
In Vivo: Troleandomycin markedly suppresses these microsomal side chain hydroxylations in both mouse and human livers in a dose-dependent manner.
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