SMER3,67200-34-4

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SMER3

CAS No. : 67200-34-4

MCE 国际站：SMER3

产品活性：SMER3 一种 Rapamycin 增强剂， 是选择性的 Skp1-Cullin-F-box (SCF)^Met30 泛素连接酶抑制剂。SMER3 通过抑制 SCF^Met30 来增强 Rapamycin 的生长抑制作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：E1/E2/E3 Enzyme

In Vitro: In yeast cells, Met4 ubiquitination is blocked in cells exposed to SMER3 (0-60 μM). The met4Δ cells are less susceptible to growth inhibition by SMER3.
Addition of SMER3 to the ligase reactions inhibited ubiquitination of Met4 by SCF^Met30 in a dose-dependent manner. SMER3 significantly inhibits the binding of Met30 to Skp1, and does not affect the Skp1 and Met30 protein levels.

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