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- 2025年12月05日
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10 mM * 1 mL///1 mg
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RORγt Inverse agonist 10
CAS No. : 2413986-35-1
MCE 国际站：RORγt Inverse agonist 10
产品活性：RORγt Inverse agonist 10 是一种有效、有口服活性的 RORγt 反向激动剂，IC50 值为 51 nM。RORγt 是银屑病发病机制相关的 IL -17A、IL-22、IL- 23r 等基因的主要转录因子。
研究领域：Metabolic Enzyme/Protease | Vitamin D Related/Nuclear Receptor
作用靶点：ROR
In Vitro: RORγt Inverse agonist 10 has a good liver microsome stability (human CLint=0.010 mL/min/mg, mouse CLint=0.030 mL/min/mg).
RORγt Inverse agonist 10 suppresses the IL-17A production in a dose-dependent manner with an IC50 of 130 nM in a human whole-blood assay.
In Vivo: RORγt Inverse agonist 10 (3-100 mg/kg; p.o.) shows robust and dose-dependent inhibitory effect on the IL-17A production in mouse IL-18/23-induced cytokine expression model.
RORγt Inverse agonist 10 (1.145 mg/kg; p.o.) shows a high AUC of 15000 nM*h and t1/2 of 3.6 hours.
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文献和实验Inverse PCR & Cycle Sequencing
where strong and unique bands do not result. Cycle on MJ Research Thermal Cycler using the following parameters (~3hr run): 1X: 95° 5 min. 35X: 95° 30 sec./(see above) 1 min./68° 2 min. 1X: 72° 10 min. 4° hold Note
In Vitro Assays of Rod and Cone Opsin Activity: Retinoid Analogs as Agonists and Inverse Agonists
transduction cascade. The native ligand, 11-cis- retinal, acts as an inverse agonist to both the apoproteins of rod and cone visual pigments (opsins); all-trans- retinal is an agonist. Truncated analogs of retinal have been used to characterize structure–
Inverse PCR for PAC-end sequencing
In strip tubes: 2.5ul Big Dye Mix 1ul Template DNA 1ul primer (one of the primers used for amplification) 3.5ul H20 cap Spin down 10" to get all products mixed at bottom Cycle sequencing - 35 cycles 94C - 15" 45C - 5" 72C
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