- ￥5800
- MedChemExpress(MCE)
- 美国
- HY-132168
- 2025年07月12日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2382768-62-7
- 规格：
1 mg
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
RMC-5552
CAS No. : 2382768-62-7
MCE 国际站：RMC-5552
产品活性：RMC-5552 是一种有效的选择性 mTORC1 抑制剂。RMC-5552 抑制 mTORC1 pS6K 和 p4EBP1 的磷酸化，IC50 分别为 0.14 nM 和 0.48 nM。RMC-5552 表现出低得多的 pAKT 抑制作用 (IC50 为 19 nM)，导致 mTORC1/mTORC2 选择性接近 40 倍。RMC-5552 具有抗癌活性。
研究领域：PI3K/Akt/mTOR
作用靶点：mTOR
In Vitro: The presence of FKBP12, whose recruitment would only be observed in the presence of the FKBP12-FRB allosteric modality of RMC-5552. Density for RMC-5552 is evident at the interface between FKBP12 and the FRB domain of mTOR. RMC-5552 makes hydrogen bonds to the backbone of G2238 and V2240, the “hinge” of mTOR, via the 4-aminopyrazolo[3,4-d]pyrimidine core, and the 2-aminobenzoxazole makes hydrogen-bonding interactions to E2190 and K2187.
In Vivo: RMC-5552 (1-10 mg/kg; i.p.; once weekly; for 28 days) exhibits antitumor activity in a human xenograft model of MCF-7 breast cancer in mice in vivo.
PK Parameters of RMC-5552 38 in Mice at 1 mg/kg via IP Administration
| compounds | Tmax (h) | Cmax (ng/mL) | Cmax (μM) | AUClast (μg/mL × h) | AUClast (μM × h) | t1/2 (h) |
| 38 RMC-5552 | 2.0 ± 0.0 | 5667 ± 1106 | 3.19 ± 0.62 | 46 089 ± 5320 | 25.9 ± 3.0 | 4.8 ± 0.4 |
相关产品：Clinical Compound Library Plus | Bioactive Compound Library Plus | Macrocyclic Compound Library | Rapamycin | Everolimus | MHY1485 | Torin 1 | AZD-8055 | Sapanisertib | Dactolisib | Salidroside | Torin 2 | Temsirolimus | L-Leucine | 3BDO | JR-AB2-011 | Omipalisib | PI-103 | Torkinib | Camonsertib | Dihydromyricetin | NV-5138 | Vistusertib | D-α-Hydroxyglutaric acid disodium | Rheb inhibitor NR1 | hSMG-1 inhibitor 11j | KU-0063794 | PF-04691502 | Aloe emodin | Polyphyllin I | Daphnetin | Samotolisib
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验maltose mcrA = Mutation eliminating restriction of DNA methylated at the sequence CmCGG (possibly mCG). Carried on the e14 prophage (q.v.) mcrB = Mutation eliminating restriction of DNA methylated at the sequence RmC metB = requires methionine metC
鼠品系如C57BL/6、NZB、CE等，此外CD161在某些T细胞亚群中也有表达。小鼠CD56 mAb并不与小鼠NK细胞反应。最近报道有一新的mAb DX5可与所有品系NK细胞反应。此外，CD122（IL- 2Rb ）、CD161a和Ly49家族（Klra,Killer cell lectin- like receptor）等标记也可用于NK的鉴定。4. Mf /Mo和DC细胞 抗Ly- 71 mAb F4/80广泛应用于小鼠组织中Mf 的分布和功能研究，此mAb与Eo、DC也有反应。小鼠CD14（rmC
Multicolour 3D-FISH in vertebrate cells
money and insures higher flexibility in designing experiments. An official source to obtain chromosome specific DNA probes is provided by M. Rocchi, University of Bari (http://www.biologia.uniba.it/rmc/). In the following section we present
技术资料暂无技术资料 索取技术资料
