Delparantag,872454-31-4

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Delparantag

CAS No. : 872454-31-4

MCE 国际站：Delparantag

产品活性：Delparantag (PMX-60056) 是一种水杨酰胺衍生物，也是一种有效的普通肝素 (UFH) 和低分子量肝素 (LMWH) 逆转剂。Delparantag 具有中和 UFH 和 LMWH 的抗凝和止血作用的能力。

研究领域：Metabolic Enzyme/Protease

作用靶点：Factor Xa

In Vitro: Delparantag is designed to restore coagulation by specifically binding to the pentasaccharide and disrupting UFH and LMWH interaction with antithrombin.
In heparinized plasma, Delparantag (PMX-60056) is more potent on a gravimetric basis than protamine at neutralizing both anti-Xa and anti-IIa activities. Delparantag is able to completely neutralize heparin at an approximate 2:1 gravimetric ratio. The amount of residual anti-IIa and anti-Xa activity was significantly less with Delparantag at a concentration of 50 mg/mL. In plasma anticoagulated with enoxaparin, Delparantag produces a concentration-dependent neutralization of anti-Xa activity. The amount of anti-Xa activity remaining after supplementation of the neutralizing agent is significantly less with Delparantag at concentrations above 25 mg/mL.

In Vivo: Delparantag (PMX-60056; 0.5 mg/kg, 1.0 mg/kg, or 2.0 mg/kg; intravenous injection; once; male Sprague-Dawley rats) treatment neutralizes the antithrombotic, anticoagulant, and bleeding effects of heparins as effectively as protamine sulfate and may be slightly more efficacious against LMWHs.
Plasma half-life elimination of Delparantag is between 3 and 5 min.

相关产品：Heparin sodium salt  |  Apixaban  |  Rivaroxaban  |  Edoxaban  |  Fondaparinux sodium  |  Gabexate mesylate  |  Betrixaban  |  Otamixaban  |  5-R-Rivaroxaban  |  Milvexian  |  Betrixaban-d6  |  BMS-962212  |  Darexaban  |  Asundexian  |  BMS-262084  |  Edoxaban impurity 4  |  Edoxaban-d6  |  Fitusiran  |  FXIa-IN-1  |  FXIa-IN-6  |  FXIa-IN-7  |  FXIa-IN-8  |  O-Desmethyl apixaban sulfate sodium  |  Razaxaban hydrochloride  |  RWJ-445167

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。