Peldesine,2772702-10-8

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Peldesine dihydrochloride

CAS No. : 2772702-10-8

MCE 国际站：Peldesine dihydrochloride

产品活性：Peldesine (BCX 34) dihydrochloride 是一种有效的，竞争性，可逆和口服活性的嘌呤核苷磷酸化酶 (PNP) 抑制剂，对人，大鼠和小鼠红细胞 (RBC) PNP 的 IC₅₀ 分别为 36 nM，5 nM 和 32 nM。Peldesine dihydrochloride 还是一种 T 细胞 (T-cell) 增殖抑制剂，IC₅₀ 为 800 nM。Peldesine dihydrochloride 可用于皮肤 T 细胞淋巴瘤，牛皮癣和 HIV 感染的研究。

研究领域：Cell Cycle/DNA Damage  |  Anti-infection

作用靶点：Nucleoside Antimetabolite/Analog  |  HIV

In Vitro: Peldesine (BCX 34; 0-50 µM; 72 hours; Jurkat cells) could inhibit the T-cell proliferation completely at a concentration of less than 10 μM, in the presence of dGuo (10 μM). In contrast, the B-cell proliferation is not affected by Peldesine.
Peldesine (BCX 34) suppresses T-cell immune reaction in an IL-2-independent manner, and this means that Peldesine might affect a late phase rather than an early stage in T-cell activation.
Peldesine also, in the presence but not in the absence of deoxyguanosine, inhibits human leukemia CCRF-CEM T-cell proliferation with an IC₅₀ of 0.57 μM but not rat or mouse T-cell proliferation up to 30 μM.

相关产品：Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Immunology/Inflammation Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Antiviral Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Rare Diseases Drug Library  |  Human Metabolite Library  |  Heterocyclic Compound Library  |  Cytokine Inhibitors Library  |  Chloroquine  |  Doxorubicin hydrochloride  |  5-Fluorouracil  |  Gemcitabine  |  Decitabine  |  5-Azacytidine  |  Cytarabine  |  5-BrdU  |  Q-VD-OPh  |  Valproic acid  |  Fludarabine  |  Panobinostat  |  Shikonin  |  Hydroxyurea  |  Probenecid  |  Kaempferol  |  Plerixafor  |  Dimethyl fumarate  |  Birinapant  |  Maraviroc  |  Capecitabine  |  Adenosine  |  Baicalin  |  Flavopiridol  |  Ritonavir  |  Uridine  |  Ivermectin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds