Darglitazone达格列酮,141200-24-0

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Darglitazone

CAS No. : 141200-24-0

MCE 国际站：Darglitazone

产品活性：Darglitazone (CP-86325)，一种噻唑烷二酮，是一种有效的，选择性的和具有口服活性的 PPAR-γ 激动剂。Darglitazone 有效控制血糖和脂质代谢，可用于 II 型糖尿病研究。

研究领域：Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor

作用靶点：PPAR

In Vitro: In cell lines representing white (3T3-L1 and 3T3-F442A) and brown (HIB-1B) adipose tissues and skeletal muscle (L6), within 4 h of exposing these cells to 30 μM Darglitazone, there is an increase in uncoupling protein 2 (UCP2) mRNA which reached a plateau of 5-10 times the basal in about 8 h. Darglitazone can stimulate the expression of UCP2 gene probably via PPAR-γ.

In Vivo: Darglitazone treatment restores euglycemia and normalized elevated corticosterone, triglycerides, and very-low-density lipoprotein levels. Darglitazone dramatically reduces the infarct size in the ob/ob mice at 24 h of recovery. Darglitazone treatment restores acute cerebral inflammatory responses that were absent in the diabetic mice and profoundly improved their recovery from hypoxic-ischemic (H/I) insult.

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