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- 2025年07月15日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1247819-59-5
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥858.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥487.0 |
| 规格： | 10 mg | 产品价格： | ￥780.0 |
| 规格： | 50 mg | 产品价格： | ￥2356.0 |
| 规格： | 100 mg | 产品价格： | ￥3800.0 |
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P 22077
CAS No. : 1247819-59-5
MCE 国际站：P 22077
产品活性：P 22077 是一种泛素蛋白特异性蛋白酶 (USP7) 抑制剂，EC50 值为 8.01 μM，同时可抑制 USP47，EC50 值为 8.74 μM。
研究领域：Cell Cycle/DNA Damage
作用靶点：Deubiquitinase
In Vitro: P 22077 is an inhibitor of USP7 and DUB USP47, with EC50s of 8.01 μM and 8.74 μM, respectively. P 22077 (15-45 μM) inhibits a much smaller subset of DUBs. P 22077 (25 μM) causes DUBs inhibition in HEK293T cells. P 22077 (0-20 μM) greatly reduces the cell viability of Neuroblastoma (NB) cells including IMR-32, NGP, CHLA-255, and SH-SY5Y cells but without NB-19 and SK-N-AS cells. P 22077 (10 μM) increases p53 activity and induces apoptosis in p53 wild-type and HDM2-expressing NB cells. P 22077 (5 μM) enhances the cytotoxic effect of Dox and VP-16 on NB cells, and enhances Dox- and VP-16-induced p53-mediated apoptosis.
In Vivo: P 22077 (15 mg/kg, i.p. 21 days) shows potent antitumor activities in an xenograft mouse model bearing IMR-32-derived tumors; P 22077 also exhibits antitumor effects after treatment at 10 mg/kg for 14 days in mice bearing SH-SY5Y-derived tumors, and at 20 mg/kg for 12 days in mice bearing NGP-derived tumors.
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文献和实验即肽酰tRNA位点(peptidyl-tRNA site), 又叫供位(donor site), 或肽酰基位点, 主要位于大亚基, 是肽基tRNA移交肽链后肽酰tRNA所占据的位置, 即与延伸中的肽酰tRNA结合位点。
Single Primer ("Semi-Random") P
Single Primer ("Semi-Random") PCR July 26, 2000 ECK Description Single primer PCR allows amplification from known to unknown regions in chromosomes, phage, plasmids, large PCR products and other sources of DNA
P-纤维素 P－ cellulose 即磷酸纤维素（ phosphocellulose），为阳离子交换纤维素的一种。
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