TEI-9648,173388-21-1

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

TEI-9648

CAS No. : 173388-21-1

MCE 国际站：TEI-9648

产品活性：TEI-9648 是一种 Vitamin D₃ Lactone 类似物，是有效的，特异性的维生素 D 受体 (VDR) 拮抗剂。TEI-9648 抑制 VDR/VDRE 介导的 1α,25(OH)₂D₃ 的基因组作用。TEI-9648 也可以抑制 1α,25(OH)₂D₃ 诱导的 HL-60 细胞分化。TEI-9648 有潜力用于骨代谢的研究。

研究领域：Vitamin D Related/Nuclear Receptor

作用靶点：VD/VDR

In Vitro: TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)₂D₃.
TEI-9648 has consistently weaker suppressive effect than TEI-9647.
TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell.
TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH)₂D₃ (0.1 nM) in HL-60 cells.

相关产品：Bioactive Compound Library Plus  |  Calcitriol  |  Calcipotriol  |  Vitamin D3  |  Calcifediol  |  Tachysterol 3  |  Paricalcitol  |  Vitamin D2  |  Ercalcidiol  |  Alfacalcidol  |  TEI-9647  |  Eldecalcitol  |  Ercalcitriol  |  Secalciferol  |  Seocalcitol  |  MeTC7  |  Maxacalcitol  |  VD3-d6  |  Inecalcitol  |  Tacalcitol  |  Vitamin D4  |  ZK168281  |  Doxercalciferol  |  VD2-d3  |  24, 25-Dihydroxy VD2  |  3-O-(2-Aminoethyl)-25-hydroxyvitamin D3

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds