Lexacalcitol来沙骨化醇,131875-08-6

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Lexacalcitol

CAS No. : 131875-08-6

MCE 国际站：Lexacalcitol

产品活性：Lexacalcitol (KH1060) 是一种维生素 D 类似物，是细胞生长和免疫反应的有效调节剂。Lexacalcitol 可用于移植排斥反应、银屑病、癌症和自身免疫性疾病的研究。

研究领域：Vitamin D Related/Nuclear Receptor

作用靶点：VD/VDR

In Vitro: Lexacalcitol inhibits cell proliferation by 50% at 10^-12 M (14,000 times more active than la,25(OH)₂D₃) in human histiocytic lymphoma cell line U 937.
Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10^-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10^-15 M.

In Vivo: Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients.

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