CU-115,2471982-20-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CU-115

CAS No. : 2471982-20-2

MCE 国际站：CU-115

产品活性：CU-115 是一种强有力的 TLR8 拮抗剂 (IC₅₀=1.04 µM)，并显示了对 TLR8 选择性高于TLR7 (IC₅₀=>50 µM)。CU-115 降低了由 R-848 激活的 THP-1 细胞 TNF-α 和 IL-1β 的产生。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: In endosomal and non-endosomal TLR specificity studies, Human embryonic kidney (HEK) 293 cells expressing human tolllike receptor (hTLR) gene and an inducible secreted embryonic alkaline phosphatase (SEAP) reporter gene were incubated with CU-115 for 16 hours. As a result, CU-115 displays activity for TLR7 and TLR8 at low concentrations (0.5 μM).
CU-115 does not modulate the NF-kB inhibition induced by Pam2CSK4, Pam3CSK4, Poly(I:C), LPS, R848, and Flic in HEK-293 TLR1/2, TLR2/6, TLR3, and TLR4 cells. And CU-115 inhibits TLR9 signaling at 1, 5, and 20 µM and ~10-25% inhibition.
CU-115 (5-20 µM) inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD in a luciferase reporter assay.
CU-115 (0.5, 1.0, 5, and 20 µM; 16 hours) is nontoxic at low concentrations (0.5 and 20 μM) and toxic at 100 μM in Hek293 TLR7 and TLR8 cells. CU-115 also is nontoxic at low concentrations (0.5 and 20 μM) and displays partial toxicity at 100 μM in THP Dual cells.
The enzyme-linked immunosorbent assay (ELISA) is performed to measure upregulation/inhibition of TNF-α in human THP-1 cells (hTHP-1). CU-115 (5-20 µM) abolishes the TNF-α production activated by R848 (1 µg/ml) in hTHP1. It also represses the expression of IL-1β in hTHP-1 cells. These results suggest that CU-115 suppresses TLR8 and TLR7 signaling pathways.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Antioxidant Compound Library  |  Oxygen Sensing Compound Library  |  Pyroptosis Compound Library  |  Antidepressant Compound Library  |  Cancer Stem Cells Compound Library  |  Pain-Related Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Autoimmune Disease Compound Library  |  Highly Selective Inhibitors Library  |  Chloroquine  |  Lipopolysaccharides  |  Resatorvid  |  Resiquimod  |  Polyinosinic-polycytidylic acid  |  C29  |  Imiquimod  |  Hydroxychloroquine sulfate  |  Enpatoran  |  Pam3CSK4 TFA  |  Sulfo-ara-F-NMN  |  CU-CPT 4a  |  ODN 1826  |  Agatolimod  |  Telratolimod  |  Vesatolimod  |  TLR4-IN-C34  |  CU-CPT22  |  Motolimod  |  Diprovocim  |  AT791  |  Complete Freund's adjuvant (CFA)  |  ABR-238901  |  CU-T12-9  |  Selgantolimod  |  TH1020

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds