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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
S44819; Egis-13529
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1398496-82-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥5500.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2000.0 |
| 规格： | 5 mg | 产品价格： | ￥5000.0 |
| 规格： | 10 mg | 产品价格： | ￥8500.0 |
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Afizagabar
CAS No. : 1398496-82-6
MCE 国际站：Afizagabar
产品活性：Afizagabar (S44819) 是一种首创的，有竞争性的，选择性的 α5-GABAAR 拮抗剂，对α5β2γ2 的IC50 值 585 nM，对 α5β3γ2 的 Ki 为 66 nM。Afizagabar 增强海马突触可塑性并显示促认知功效。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：GABA Receptor
In Vitro: Afizagabar (S44819) is a competitive α5-GABAAR antagonist (Kb=221 nM). Afizagabar selectively inhibits extrasynaptic α5-GABAARs of mouse CA1 pyramidal neurons.
In Vivo: Afizagabar (1 and 3 mg/kg; i.p.) significantly diminishes the marked increase in total errors induced by Scopolamine.
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