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货期：电询
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MedChemExpress LLC
- CAS号：
501081-38-5
- 规格：
电询
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FGI-106
CAS No. : 501081-38-5
MCE 国际站：FGI-106
产品活性：FGI-106 是一种有效的广谱抑制剂，对多种病毒具有抑制活性。FGI-106 具有抗埃博拉病毒 (EBOV)，裂谷病毒 (Rift Valley virus) 和登革热病毒 (Dengue Fever virus) 的活性，其 EC50 分别为 100 nM，800 nM 和 400-900 nM。FGI-106 还分别以 EC50 值为 200 nM 和 150 nM 抑制非失血性发热病毒 HCV 和 HIV-1。
研究领域：Anti-infection
作用靶点：Flavivirus | HCV | HIV
In Vitro: Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM.
In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.
In Vivo: FGI-106 (0.1-5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment decreases mortality from Zaire EBOV in a dose-dependent manner.
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